Local Radiotherapy Affects Drug Pharmacokinetics—Exploration of a Neglected but Significant Uncertainty of Cancer Therapy
Journal
Technology in Cancer Research and Treatment
Journal Volume
16
Journal Issue
6
Date Issued
2017
Author(s)
Abstract
Concurrent chemoradiation therapy is the mainstay of treatment for many types of malignancies. However, concurrent chemoradiation therapy is associated with a greater number of systemic adverse effects than radiotherapy or chemotherapy alone.
Subjects
RT-PK phenomenon; concurrent chemoradiation therapy; pharmacokinetics; radiotherapy; uncertainty
SDGs
Other Subjects
anti programmed death 1 receptor antibody; cisplatin; fluorouracil; interleukin 16; interleukin 18; interleukin 2; interleukin 4; neutrophil collagenase; reactive nitrogen species; transforming growth factor beta1; tumor necrosis factor; unclassified drug; antineoplastic agent; cisplatin; neutrophil collagenase; area under the curve; biliary excretion; cancer chemotherapy; cancer palliative therapy; cancer radiotherapy; chemoradiotherapy; human; lymphatic system; radiosensitivity; Review; adverse drug reaction; genetics; multimodality cancer therapy; neoplasm; pathology; Antineoplastic Agents; Chemoradiotherapy; Cisplatin; Combined Modality Therapy; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Humans; Matrix Metalloproteinase 8; Neoplasms
Type
review