The Clinical Application of Functional Magnetic Resonance Imaging in Ischemic Stroke – Final Repor t
Date Issued
1999-07-31
Date
1999-07-31
Author(s)
黃國茂
DOI
882314B002032M08
Abstract
The three-year research project
intended to develop new techniques of
functional magnetic resonance imaging
(fMRI) and its clinical application on
ischemic stroke in three different stages.
In our first yea plan, we collected the
normal data of fMRI from visual and
motor stimulations. In the second year,
we collect data from patients with
ischemic brain infarcts. In the last year we
emphasizing the influence of time factor
after the stroke episode. The basic
principle of our experiment is so called
“blood oxygen level dependent” (BOLD)
effect. The experiment was implemented
on a clinical machine of 1.5 T GE Signa
and Siemens Magneton (with EPI). The
pulse sequence for imaging acquisition
was T2WI such as “FLASH” in gradient
echo or EPI. The experiment was carried
out with the finger tapping movement and
8-Hz flash light visual stimulation in
normal subjects. The functional images
first went through the post- processing of
correlation coefficient. Those pixels
highly correlated (p < 0.001) with an
assumed input function were mapped
back on to structure images. Further
quantitation was perfomed on signal
intensity and relative index of regional of
interest (ROI ). The analysis showed in
the acute stage, the response on the lesion
side was weaker than the sound side.
However, in the chronic stage the
response being more complicated and
worth further study.
Subjects
Functional Magnetic Resonance
Imaging
Imaging
Visual Cortex
Motor Cortex
Hemoglobin
Ischemic Stroke
Publisher
臺北市：國立臺灣大學醫學院放射線科
Type
journal article
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