GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm
Journal
Biochimica et Biophysica Acta - Molecular Cell Research
Journal Volume
1867
Journal Issue
11
Date Issued
2020
Author(s)
Abstract
GSK3 are involved in different physical and pathological conditions and inflammatory regulated by macrophages contribute to significant mechanism. Infection stimuli may modulate GSK3 activity and influence host cell adaption, immune cells infiltration or cytokine expressions. To further address the role of GSK3 modulation in macrophages, the signal transduction of three major organs challenged by endotoxin, virus and genetic inherited factors are briefly introduced (lung injury, myocarditis and autosomal dominant polycystic kidney disease). As a result of pro-inflammatory and anti-inflammatory functions of GSK3 in different microenvironments and stages of macrophages (M1/M2), the rational resolution should be considered by adequately GSK3. ? 2020 Elsevier B.V.
Subjects
HMGB1/IL-17A/autophagy; M1/M2 macrophages; Mitotic catastrophe; PI3K/Akt/GSK3β/MCP-1 axis; Podocyte; Pulmonary edema
SDGs
Other Subjects
cytokine; endotoxin; glycogen synthase kinase 3; glycogen synthase kinase 3beta; macrophage migration inhibition factor; monocyte chemotactic protein 1; glycogen synthase kinase 3beta; GSK3B protein, human; acute lung injury; adult respiratory distress syndrome; aneurysm; cell infiltration; cell migration; cholinergic system; congestive cardiomyopathy; disease association; heart protection; human; immunocompetent cell; immunomodulation; infection; inflammation; kidney polycystic disease; macrophage; myocarditis; nonhuman; priority journal; protein expression; renal protection; Review; signal transduction; acute lung injury; aneurysm; genetics; kidney polycystic disease; lung injury; metabolism; myocarditis; pathology; Acute Lung Injury; Aneurysm; Glycogen Synthase Kinase 3 beta; Humans; Lung Injury; Macrophages; Myocarditis; Polycystic Kidney Diseases
Type
review