Clinical and Pathophysiological Assessment of the Skin Reactions in Nasopharyngeal Carcinoma Patients Receiving Radiotherapy
Date Issued
2007
Date
2007
Author(s)
Chiu, Wen-Tzu
DOI
zh-TW
Abstract
The purpose of this repeated measurement study is measure skin function and morphology weekly during radiotherapy. The 19 patients enrolled this study from Jan 16 to June 8, 2007. Measurement of tools were use Corneometer, Mexameter, and Laser Doppler Image for analysis skin function, RTOG skin reaction scores and the self-reports of patients. Statistics analysis was use software of SPSS 15.0, generalized estimating equations method.
This study found water loss of cutonaus with the accumulated dose had negative relative. However, skin color analysis, microcirculation change and self-report of symptom with radiation accumulated dose had positive relative doses. The symptom of "erythema”, “discoloration”, and “skin itching” have significance relative of self-report of symptom. The symptom distress and physical assessment had changed from 20 Gy, the peak stage at over 60Gy. Radiation induced skin damage influence factor had age, radiation doses, received induction chemotherapy, microcirculation change, and skin intervention. Another, this study found microculatin change with increased radiation doses had positive relative(p=.000，β= .292), but if had skin damage, microculatin changed to negative relative (p=.034β= -.844). In conclusion, blood perfusion with radiation therapy induced skin damage had very important machism. Therefore, early detection of these reactions for better care is further in research of radiation- dermatology and radiation nursing.
Subjects
放射性皮膚反應
放射性皮膚之生理病理
微血循環灌流改變
rediation-induced skin reaction
Pathophysiology of skin reaction
microciculation change
Type
other
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