Cytochrome P4501a1 Polymorphism as a Susceptibility Factor for Breast Cancer in Postmenopausal Chinese Women in Taiwan
Resource
BRITISH JOURNAL OF CANCER v.80 n.11 pp.1838-1843
Journal
BRITISH JOURNAL OF CANCER
Journal Volume
v.80
Journal Issue
n.11
Pages
1838-1843
Date Issued
1999
Date
1999
Author(s)
HUANG, CHIUN-SHENG
Abstract
The incidence of breast cancer has been greatly increasing in Taiwan over the past two decades. Since cytochrome P4501A 1 (CYP1A1) is involved in the metabolism of environmental carcinogens or oestrogen, we hypothesized that CYP1A1 genetic polymorphism may be a susceptibility factor for breast cancer. This hypothesis was evaluated in this case control study of 150 breast cancer patients and 150 healthy controls among Chinese women. Two CYP1A1 polymorphisms were studied, one containing a new Msp1 site and the other located in axon 7 and resulting in the replacement of an isoleucine (Ile) residue by a valine (Val). After simultaneously considering the known or significant risk factors for breast cancer, including the age of study participants, positive family history of breast cancer, early menarche (< or = 13 years), nulliparity and late first full-term pregnancy (> or = 30 years), hormone replacement therapy and smoking, the CYP1A1 Msp1 polymorphism was found to be a significant factor in determining the risk
Subjects
LUNG-CANCER
CYP1A1 GENE
CIGARETTE-SMOKING
AMERICAN WOMEN
DNA-ADDUCTS
BODY-SIZE
SDGs
Type
journal article