Chemical Modification and Site-directed Mutagenesis of Cys and Arg of the Sialic Acid Synthase from Streptococcus agalactiae
Date Issued
2004
Date
2004
Author(s)
Chen, Jui-Chuan
DOI
zh-TW
Abstract
B型無乳鏈球菌（Group B Streptococcus agalactiae）含唾液酸的莢膜，能避免補體C3b的沉澱或巨噬細胞的吞噬，使菌體可經由垂直感染造成新生兒敗血症或腦膜炎。莢膜多醣的產生及其結構的完整性，已被報導為該菌的致病毒性因子。而唾液酸位於莢膜上寡醣單元（NeuAc-
Streptococcus agalactiae is a primary cause of neonatal morbidity and mortality. The production of a type-specific capsular polysaccharide (CPS) is essential to the virulence of this pathogen and enables the bacteria to evade host immue defenses. As a key component of the capsular polysaccharide, sialic acid (or N-acetylneuraminic acid) is
Subjects
唾液酸合成酶
sialic acid synthase
Type
other
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