Prognostic roles of pathology markers immunoexpression and clinical parameters in Hepatoblastoma
Journal
Journal of Biomedical Science
Journal Volume
24
Journal Issue
1
Pages
62
Date Issued
2017
Abstract
Background: Hepatoblastoma, a leading primary hepatic malignant tumor in children, is originated from primitive hepatic stem cells. We aimed to elucidate the relationships between the histological distribution of β-catenin and hepatic stem cell markers with the clinical outcomes of hepatoblastoma. Methods: Immunohistochemistry was applied to detect β-catenin and hepatic stem cell markers expression in 31 hepatoblastoma tumors. We analyzed the relationship between the stem cell markers and the clinical course of hepatoblastoma. Results: Thirty-one hepatoblastoma patients were diagnosed at a mean age of 2.58 ± 3.78 years, and 7 (22.58%) died. A lack of anticipated decrease in alpha-fetal protein levels after neoadjuvant chemotherapy indicated a higher mortality rate. Nuclear β-catenin expression was significantly associated with membranous epithelial cell adhesion molecule (EpCAM) expression in hepatoblastoma tumor specimens. The co-expression of nuclear β-catenin and membranous EpCAM together with an age at diagnosis ?1.25 years were predictive of an alpha-fetoprotein level < 1200 ng/mL after neoadjuvant chemotherapy (P < 0.05). An alpha-fetoprotein level < 1200 ng/mL after neoadjuvant chemotherapy and age at hepatoblastoma diagnosis ?1.25 years are both predictors of better overall and native liver survival in hepatoblastoma patients. Conclusions: Presence of membranous EpCAM with nuclear β-catenin and younger diagnostic age of hepatoblastoma are predictive of serum alpha-fetoprotein levels drop after chemotherapy. Younger diagnostic age and lower alpha-fetoprotein levels after neoadjuvant chemotherapy and are predictive of better overall and native liver survival in hepatoblastoma patients. ? 2017 The Author(s).
SDGs
Other Subjects
alpha fetoprotein; beta catenin; cytokeratin 19; epithelial cell adhesion molecule; tumor marker; beta catenin; CTNNB1 protein, human; epithelial cell adhesion molecule; tumor marker; Article; cancer mortality; cancer prognosis; cancer survival; child; clinical article; clinical outcome; disease course; disease marker; female; hepatoblastoma; histology; human; immunohistochemistry; liver cell; male; mortality rate; neoadjuvant chemotherapy; overall survival; prediction; preschool child; priority journal; protein blood level; protein expression; stem cell; cancer stem cell; gene expression; genetics; hepatoblastoma; immunology; infant; liver tumor; metabolism; prognosis; beta Catenin; Biomarkers, Tumor; Child; Child, Preschool; Epithelial Cell Adhesion Molecule; Female; Gene Expression; Hepatoblastoma; Humans; Infant; Liver Neoplasms; Male; Neoplastic Stem Cells; Prognosis
Publisher
BioMed Central Ltd.
Type
journal article