Studies on the Synthesis of Poly(ethyl cyanoacrylate) Nanoparticles as Drug Carrier Systems
Date Issued
2014
Date
2014
Author(s)
Lee, Yi-Chieh
Abstract
In Taiwan, we are entering aging society. Taiwan Alzheimer’s Disease Association estimates that the population of dementia in Taiwan will be near to 800000 in 2060. Alzheimer’s disease makes up the greatest number of cases among all causes of dementia. Therefore, how to prevent and cure Alzheimer’s disease effectively is becoming an important issue.
Clioquinol is one of the metal chelating agent and has been found to be beneficial in the treatment for Alzheimer''s disease. While clioquinol itself cannot easily pass through the blood brain barrier, the research showed that, with nanoparticles used as the drug carriers, the targeting property/feature of the drug carriers would aid in the passage of clioquinol across the blood brain barrier and thus exerting its effects.
Many studies have demonstrated that, due to their biocompatibility and biodegradability, poly alkyl cyanoacrylates (PACA), and poly butyl cyanoacrylate (PBCA) can be used as the drug carriers and help the drugs reach the destination. In this thesis, the poly ethyl cyanoacrylate (PECA) was used as a drug carrier system. In order to obtain the proper size of PECA nanoparticle drug carrier to pass the blood brain barrier, several key parameters of the synthesis of PECA nanoparticle drug carriers were examined. The important properties/features along with the drug release rates of the PECA nanoparticle drug carrier were also determined. We believe the outcome from this research may contribute to the treatment for Alzheimer’s disease.
Subjects
阿茲海默症
血腦屏障
Clioquinol
聚氰基丙烯酸乙酯
Type
thesis
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