肺臟過度表現胎盤生長因子對肺臟發育的影響
Date Issued
2003
Date
2003
Author(s)
曹伯年
DOI
912314B002187
Abstract
After the widespread use of antenatal steroid, exogenous surfactant therapy, and improvements in neonatal care, the survival rate of very low birth weight infants has increased, but bronchopulmonary dysplasia (BPD) persists as one of the major complications in premature infants who need prolonged ventilator support. The incidence of BPD ranges between 15 and 50%.
The etiology of BPD included the immaturity, prolonged oxygen therapy, barotrauma, and infection. The pathological finding in the premature infants with BPD include alveolar hypoplasia, vascular arrest and adaptive dysmorphic changes, and variable interstitial proliferation.
During the period of alveolarization, the lung also undergoes marked vascular growth as reflected by the 20-fold increase in alveolar and capillary surface areas from birth to adulthood. Mechanisms that increase vascular surface area during late gestation and the early postnatal period are poorly understood, but it is clear that coordination of distal air space and vascular growth is essential for normal lung development.
Vascular endothelial growth factor (VEGF) family has been found to play an important role in vascuogenesis and angiogenesis. It has been well established that disrupted pulmonary vasculature and decreased VEGF and Flt-1, but no changes in Flk-1, in human infants dying with BPD. However, the role of PlGF, another ligand of Flt-1, in lung development is unknown. In our previous study, we found that overexpression of PlGF, using CMV promotor, seems disrupt pulmonary alveolarization. It give us a hint that PlGF may play an important role in lung development.
In this current project, we have used lung-specific promotor, SP-C (a gift from Dr. Whitsett, University of Cincinnati), to produce targeted expression of PlGF transgenic mice. Therefore, we will understand the directed role of PlGF in lung development. In addition, we can use this model to study the mechanism of alveolarization and try to find a way to rescue the poor alveolarization of BPD.
Subjects
Bronchopulmonary dysplasia
vascular endothelial growth factor
angiopoietin
placenta growth factor
Publisher
臺北市：國立臺灣大學醫學院小兒科
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
912314B002187.doc
Size
497.5 KB
Format
Microsoft Word
Checksum
(MD5):81121d99287bc4be72c3281cd34fbec5