The effect of endotoxin adsorber hemoperfusion on microcirculation in patients with severe sepsis and septic shock
Journal
Intensive Care Medicine Experimental
Journal Volume
3
Journal Issue
S1
Date Issued
2015-01-01
Author(s)
Abstract
Microcirculatory dysfunction may result in multiple organ dysfunction during severe sepsis and septic shock. (1) A meta-analysis of randomized trials showed that polymyxin B hemoperfusion (PMX-HP), plasma exchange, and hemofiltration were associated with lower mortality. (2) Mesenteric microcirculation was better maintained with polymyxin B hemoperfusion in one rat sepsis study. (3) However, the effects of polymyxin B hemoperfusion on the microcirculation in patients with severe sepsis and septic shock was unknown.
SDGs
Type
other