Usefulness of (Ti)-T-201 Spect/Ct Relative to F-18-Fdg Pet/Ct in Detecting Recurrent Skull Base Nasopharyngeal Carcinoma
Resource
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK v.31 n.6 pp.717-724
Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Journal Volume
v.31
Journal Issue
n.6
Pages
717-724
Date Issued
2009
Date
2009
Author(s)
YEN, RUOH-FANG
TING, LAI-LEI
CHENG, MEI-FANG
WU, YEN-WEN
TZEN, KAI-YUAN
HONG, RUEY-LONG
Abstract
Background. This study was designed to compare (TI)-T-201 single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose (F- 18-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC). Methods . Twenty-seven patients were recruited. Both (TI)-T-201 SPECT/CT and F-18-FDG PET/CT for each patient were performed at least 4 months later after initial therapy. Results. The sensitivity and specificity for (TI)-T-201 SPECT/CT were 66 .7% and 100%, and those for F- 18-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/ background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios. Conclusion. (TI)-T-201 SPECT/ CT is as effective as F-18-FDG PET/CT in detecting recurrent NPC. For intracranal recurrence, (TI)-T-201 SPECT, because of its high intracranial lesion/background ratio, is probably better than F-18-FDG PET.
Subjects
(TI)-T-201 SPECT/CT
F-18-FDG PET/CT
nasopharyngeal carcinoma
recurrence
skull base