行政院國家科學委員會專題研究計畫成果報告:翳狀贅片 Telomerase 活性之研究
Date Issued
1999
Date
1999
Author(s)
王一中
DOI
882314B002380
Abstract
Pterygium is a degenerative corneal
limbal process characterized by the triangular
conjunctival invasion onto the cornea (1,2).
The histopathological pictures include an
atrophic conjunctival epithelium and a highly
vascularized bulky mass of hypertrophic and
elastotic degenerated connective tissue (3).
On the corneal side under the head of
pterygium, fibroblasts penetrate Bowman's
layer basement membrane. The invasive
characteristics of pterygial fibroblasts seem
to like the transformed cells such as tumor
cells(4-10). In the previous study pterygial
fibroblasts showed the phenotype of
semitransformed cells, including lower serum
requirement、higher saturation cell density、
lower requirement of exogenous growth
factors and colony formation in soft agar
culture、digestion of the basement membrane
of epithelium, but no tumor formation after
pterygial fibroblast subcutaneous injection in
nude mice (11). The epidemiological and
mathematical studies showed that the
formation pterygium was correlated with the
UV irradiation (12,13). Whether the
semitransformed characteristics of pterygial
fibroblasts are due to ultraviolet irradiation is
highly speculated.
Subjects
專題計畫
報告格式
國科會
Publisher
臺北市：國立臺灣大學醫學院眼科
Type
journal article
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