The Association between Total Urinary Arsenic Concentration and Renal Dysfunction in a Community-Based Population from Central Taiwan
Resource
CHEMOSPHERE v.84 n.1 pp.17-24
Journal
Chemosphere
Pages
17-24
Date Issued
2011
Date
2011
Author(s)
CHEN, JEIN-WEN
LI, WAN-FEN
LIOU, SAOU-HSING
CHEN, CHIEN-JEN
WANG, SHU-LI
Abstract
Arsenic (As) is an important environmental toxicant that can cause cancer and cardiovascular disease, but the relationship between As exposure and renal dysfunction is not clear. The aim of this study is to examine the association between As exposure and renal dysfunction in a community-based population in central Taiwan. One thousand and forty-three subjects were recruited between 2002 and 2005. The risk for type 2 diabetes was increased by 2-fold ( p < 0.05) in subjects with total urinary As (U-As) > 75 mu g g(-1) creatinine as compared with subjects whose U-As was <= 35 mu g g(-1) creatinine after the adjustment for potential confounders. The adjusted odds ratio for an abnormal beta 2 microglobulin (B2MG > 0.154 mg L-1) was significantly higher in subjects with U-As > 35 mu g g(-1) creatinine as compared with the reference group adjusted for age, sex, living area, cigarette smoking, diabetes, and hypertension. The risk for abnormal B2MG and estimated glomerular filtration rate (eGFR < 90 mL min(- 1) (1.73 m(2)) (-1)) was both increased around 2-fold (p < 0.05) in subjects with U-As > 75 mu g g(-1) creatinine as compared with those with U-As (35 mu g g(-1) creatinine adjusted for all the risk factors plus lead (Pb), cadmium and nickel. The prevalence of abnormal B2MG was 4.82 times higher in subjects with both over the median levels of U-As (85.1 mu g L-1 ) and urinary Pb (18.9 mu g L-1) as compared to both lower than the median (p < 0.001). These results indicate that U-As might relate to renal dysfunction even other important risk factors were taken into account. Follow-up studies for causal inference are warranted.
Subjects
Arsenic
Renal dysfunction
Type 2 diabetes mellitus
Glomerular filtration rate
Environmental epidemiology
SDGs
Other Subjects
Arsenic; Diseases; Beta-2-microglobulin; Cardio-vascular disease; Cigarette smoking; Environmental epidemiology; Environmental toxicants; Glomerular filtration rate; Renal dysfunction; Type 2 diabetes mellitus; Risk perception; arsenic; beta 2 microglobulin; cadmium; creatinine; lead; nickel; age structure; cancer; cardiovascular disease; community structure; concentration (composition); epidemiology; filtration; health risk; heavy metal; population structure; risk factor; sex ratio; urine; adult; article; beta 2 microglobulin urine level; cigarette smoking; controlled study; creatinine urine level; disease association; female; glomerulus filtration rate; human; hypertension; kidney dysfunction; major clinical study; male; non insulin dependent diabetes mellitus; risk; risk factor; Taiwan; urinalysis; Taiwan