Increased risk of depressive disorder following cholecystectomy for gallstones
Journal
PLoS ONE
Journal Volume
10
Journal Issue
6
Date Issued
2015
Author(s)
Abstract
Background: Prior studies indicate a possible association between depression and cholecystectomy, but no study has compared the risk of post-operative depressive disorders (DD) after cholecystectomy. This retrospective follow-up study aimed to examine the relationship between cholecystectomy and the risk of DD in patients with gallstones in a population-based database. Methods: Using ambulatory care data from the Longitudinal Health Insurance Database 2000, 6755 patients who received a first-time principal diagnosis of gallstones at the emergency room (ER) were identified. Among them, 1197 underwent cholecystectomy. Each patient was then individually followed-up for two years to identify those who were later diagnosed with DD. Cox proportional hazards regressions were performed to estimate the risk of developing DD between patients with gallstone who did and those who did not undergo cholecystectomy. Results: Of 6755 patients with gallstones, 173 (2.56%) were diagnosed with DD during the two-year follow-up. Among patients who did and those who did not undergo cholecystectomy, 3.51% and 2.36% later developed depressive disorder, respectively. After adjusting for the patient's sex, age and geographic location, the hazard ratio (HR) of DD within two years of gallstone diagnosis was 1.43 (95% CI, 1.02-2.04) for patients who underwent cholecystectomy compared to those who did not. Females, but not males, had a higher the adjusted HR of DD (1.61; 95% CI, 1.08-2.41) for patients who underwent cholecystectomy compared to those who did not. Conclusions: There is an association between cholecystectomy and subsequent risk of DD among females, but not in males. ? 2015 Tsai et al.
SDGs
Other Subjects
adult; Article; cholecystectomy; cohort analysis; controlled study; depression; female; follow up; gallstone; geographic distribution; high risk patient; human; major clinical study; male; middle aged; postoperative period; retrospective study; risk assessment; sex difference; survival rate; Taiwan; adverse effects; aged; cholecystectomy; complication; Depressive Disorder; Gallstones; proportional hazards model; risk; Adult; Aged; Cholecystectomy; Depressive Disorder; Female; Gallstones; Humans; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Risk
Publisher
Public Library of Science
Type
journal article