CD8 T 細胞在對胞內菌保護性免疫反應的角色(2/3)
Date Issued
2003
Date
2003
Author(s)
伍安怡
DOI
912320B002096
Abstract
As new evidence showed that exogenous antigens can be presented via MHC
class I pathway in professional antigen-presentation cells, the role of CD8 T cells in
protective immunity against endosomal pathogen of the macrophages needs to be
re-examined. Our data have shown that not only CD4 but also CD8 T cells were
actively engaged in IFN γ production in response to intracellular Histoplasma
infection. Although the magnitude of CD4 T cell response was greater than that of
CD8 T cells, the kinetics of the expansion and contraction of both cell types followed
the same pattern. Furthermore, CD8 T cells were of critical importance for the
protective response against Histoplasma infection in the absence of CD4 T cells.
Depletion of CD8 T cells in IIKO mice not only disrupted the maintenance of fungal
load in spleens, but also caused 100% mortality after 5 weeks of infection. Moreover,
as well as IFN γ production, CD8 T cells had cytotoxic activity that could lyse
Histoplasma lysate-pulsed bone marrow-derived macrophages. Our results
demonstrated that CD8 T cells participate in the protective immune response to
disseminated infection with Histoplasma by IFN γ secretion and cytotoxicity.
Although the response is minor as compared with CD4 T cells, CD8 T cells are
important in the absence of CD4 T cells.
Publisher
臺北市：國立臺灣大學醫學院免疫學研究所
Type
journal article
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