Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana
Journal
Tetrahedron Letters
Journal Volume
52
Journal Issue
4
Pages
515 - 517
Date Issued
2011
Author(s)
Hsien, Chin-Lin
Tseng, Mei-Hwei
Pan, Ryh-Nan
Chang, Jang-Yang
Kuo, Ching-Chuan
Kuo, Yueh-Hsiung
Abstract
Chemical investigation of the bark of Calocedrus macrolepis var. formosana, an endemic tree in Taiwan, has led to the isolation of a novel terpenoid 1. Compound 1 with a rare C35 skeleton constructed by a diterpene and a sesquiterpene moieties. Its structure was elucidated by spectroscopic interpretations. The anti-proliferation activity of 1 against human oral epidermoid carcinoma KB cells was evaluated, and the IC50 value was determined to be 9.2 ± 0.4 μM. © 2010 Elsevier Ltd. All rights reserved.
SDGs
Type
journal article