Expression of adhesion molecules in the mucosa of the nose and sinus
Journal
Journal of the Otolaryngological Society of the Republic of China
Journal Volume
32
Journal Issue
6
Pages
662-669
Date Issued
1997
Author(s)
Liu C.-M.
Abstract
Background: To understand the manifestation and significance of vascular endothelial adhesion molecules in the nasal and sinus mucosa in different inflammatory state, an immunohistochemical study of the mucosa of the nose and sinus was conducted about intercellular adhesion molecule-1 (ICAM-1), endothelial leukocyte adhesion molecule-1 (ELAM-1), and vascular cell adhesion molecule-1 (VCAM-1) which mostly appear on vascular endothelium. Methods: The mucosa taken from the inferior turbinates of normal subjects (n=6), and patients with nonallergic rhinitis (n=15), perennial allergic rhinitis (n=8), and chronic sinusitis (n=12), and mucosa from the maxillary sinus of normal subjects (n=4), and patients with chronic sinusitis (n= 12)and polyps from chronic sinusits patients (n=8) were used for immunohistochemical staining of ICAM-1, ELAM-1 and VCAM-1. Results: ELAM-1 and VCAM-1 were observed in weak intensity and expression rate in normal mucosa, but VCAM-1 manifested with low level increased in diseased specimens. ICAM-1 was normally present and increased in most diseased mucosa. There was significant difference of ICAM-1 level between normal and diseased mucosa, but there was no difference among diseased groups. Conclusion: There results suggest that endothelial adhesion molecules are involved in mucosal inflammation and ICAM-1 may contribute to chronic inflammation cell infiltration.
Subjects
Adhesion molecule; Chronic inflammation; Rhinitis; Sinusitis
SDGs
Other Subjects
cell adhesion molecule; endothelial leukocyte adhesion molecule 1; intercellular adhesion molecule 1; vascular cell adhesion molecule 1; antigen expression; article; cell infiltration; chronic inflammation; chronic sinusitis; controlled study; facial bone; human; human tissue; major clinical study; nose mucosa; nose polyp; paranasal sinus; rhinitis
Type
journal article