Metabolic syndrome associated with reduced lower urinary tract symptoms in middle-aged men receiving health checkup
Journal
Urology
Journal Volume
80
Journal Issue
5
Pages
1093-1097
Date Issued
2012
Author(s)
Abstract
Objective: To investigate the impact of metabolic syndrome on lower urinary tract symptoms in a sample of middle-aged men receiving a health checkup. Methods: Subjects aged 45 years or older who voluntarily underwent a medical checkup were enrolled. Participant demographics and health history were collected by a self-administered questionnaire. All participants were stratified into 2 groups by the presence of metabolic syndrome, as defined according to the updated National Cholesterol Education Program's Adult Treatment Panel III. Prostate volume and prostate-specific antigen levels were used for subgroup analysis. Results: During January through December of 2010, 708 subjects with a mean age of 55.6 ± 9.72 years were enrolled into the study. Compared to the nonmetabolic syndrome group, the metabolic syndrome group had lower total international prostatic symptoms score (7.89 ± 6.63 vs 6.85 ± 6.52, P =.05) and lower severity of weak urinary stream (1.24 ± 1.60 vs 0.95 ± 1.50, P =.021). In the higher prostate volume group (prostate volume <30 mL), total international prostatic symptoms score, storage score, and urinary frequency, urgency and incomplete emptying were lower in men vs those without metabolic syndrome (all P <.05). The negative association between voiding score, severity of lower urinary tract symptoms, and metabolic syndrome became particularly pronounced as the number of metabolic syndrome factors increased (P for trend <.01). Conclusion: We confirmed that metabolic syndrome had favorable effects on lower urinary tract symptoms, including voiding and storage symptoms in healthy middle-aged men. This beneficial effect was most significant in men with enlarged prostate and/or high prostate specific antigen levels. ? 2012 Elsevier Inc.
Other Subjects
prostate specific antigen; adult; article; controlled study; demography; disease association; disease severity; human; impaired bladder emptying; lower urinary tract symptom; major clinical study; male; metabolic syndrome X; periodic medical examination; priority journal; prostate hypertrophy; questionnaire; urinary frequency; urinary urgency; Disease Progression; Endosonography; Follow-Up Studies; Humans; Lower Urinary Tract Symptoms; Male; Mass Screening; Metabolic Syndrome X; Middle Aged; Prostate; Prostate-Specific Antigen; Prostatic Hyperplasia; Quality of Life; Questionnaires; Retrospective Studies; Urination
Type
journal article