Investigation of the Therapeutic Effect of Doxorubicin Combined With Focused Shockwave on Glioblastoma
Journal
Frontiers in oncology
Journal Volume
11
Date Issued
2021
Author(s)
Abstract
Glioblastoma multiforme (GBM) is currently the most devastating brain tumor globally and produces a high mortality rate. GBM is also challenging to eradicate using surgery due to its invasive characteristics. Moreover, the blood-brain barrier (BBB) increases the difficulty of transporting most therapeutic drugs to tumor sites. The use of transcranial focused ultrasound (FUS) has recently been investigated for opening the BBB to facilitate drug delivery. A special form of FUS, the shockwave (SW), has also been shown to open BBB efficiently. SW has several advantages including no heating effect, less reactive oxygen species production, good transcranial ability, and no need to supply microbubbles.
Subjects
BBB; blood-brain barrier; doxorubicin; glioblastoma multiforme; shockwave
Type
journal article