Characterization of a cadmium-inducible isoform of pyruvate carboxylase from Caenorhabditis elegans
Journal
Mitochondrial DNA
Journal Volume
12
Journal Issue
2
Pages
137-145
Date Issued
2001
Author(s)
Freedman, J.H.
Abstract
A homologue of pyruvate carboxylase was isolated as an expressed sequence tag during the identification of cadmium-responsive genes in Caenorhabditis elegans. The C. elegans protein, designated PYC-1, is predicted to contain 1,175 amino acids with a molecular mass of 129,284. Amino acid sequence analysis indicates that PYC-1 will be translocated into mitochondria. PYC-1 has high levels of amino acid sequence identity with other pyruvate carboxylases. The highest levels of identity are in the putative transcarboxylation, biotin carboxylation and biotin carboxyl carrier domains.
Type
journal article