Biophysical analysis of cancer stem cell-potent copper(ii) coordination complexes
Journal
Dalton Transactions
Journal Volume
48
Journal Issue
18
Start Page
8398
End Page
5896
ISSN
14779226
Date Issued
2019
Author(s)
Abstract
Copper(ii) coordination complexes, 1 and 2, containing nonsteroidal anti-inflammatory drugs (NSAIDs) potently kill breast cancer stem cells (CSCs) and bulk breast cancer cells. Although detailed biological studies have been conducted to shed light on their mechanism of cytotoxicity, little is known about their molecular level mechanism of action. This biophysical study, aided by the preparation of a fluorophore-containing analogue, 3, reveals that the complexes operate by undergoing reduction to a copper(i) form and releasing the associated NSAIDs. This journal is © The Royal Society of Chemistry.
Publisher
Royal Society of Chemistry
Description
論文編號: 8398
Type
journal article