Non-invasive Small Animal Tumor Growth Imaging: High Frequency Ultrasound VS. MicroPET
Journal
Symposium of Annual Conference of the Biomedical Engineering Society
Pages
5695-5698
Date Issued
2005-12
Author(s)
Abstract
Tumor volume measurement on small animals Is important but currently invasive. We employ ultrasonic micro-imaging (UMI) in this study and demonstrate its feasibility. In addition, we use small animal positron emission tomography (microPET) as a preliminary effort to develop multi-modality small animal imaging techniques. The tumor growth curve from UMI is also compared to radioactivity from microPET. Both UMI and [18F]FDG microPET imaging were performed on C57BL/6J black mice bearing WF-3 ovary cancer cells at various stages from the second week till up to the eighth week. Segmentation and 3D reconstruction were also done. The growth curve was obtained in vivo noninvasively by UMI. The cell doubling time was 7.46 days according to UMI. This result was compared with vernier caliper measurement and radioactivity counting by microPET. In microPET, we obtained the time-activity curves from the tumor and the tumor-surrounding tissue. The tumor-to-normal-tissues ratios reached maximum at the fifth week after tumor cell implantation. ? 2005 IEEE.
SDGs
Other Subjects
Cells; Image reconstruction; Image segmentation; Imaging techniques; Positron emission tomography; Radioactivity; Ultrasonics; Caliper measurement; Non-invasive imaging; Ovary cancer cells; Ultrasonic micro-imaging (UMI); Tumors
Type
conference paper