A Common Polymorphism in the Scn1a Gene Associates with Phenytoin Serum Levels at Maintenance Dose
Resource
PHARMACOGENETICS AND GENOMICS v.16 n.10 pp.721-726
Journal
PHARMACOGENETICS AND GENOMICS
Journal Volume
v.16
Journal Issue
n.10
Pages
721-726
Date Issued
2006
Date
2006
Author(s)
HUNG, CHIN-CHUAN
TAI, JOHN JEN
LIOU, HORNG-HUEI
Abstract
Objectives A broad range of phenytoin doses is used in clinical practice, with the final 'maintenance' dose normally determined by trial and error. A common functional polymorphism in the SCN1A gene (one of the genes encoding the drug target) has been pre
Subjects
association genetics
drug response
epilepsy
maintenance dose
pharmacodynamics
pharmacogenetics
Type
journal article