Efficacy of ultrafiltration in removing inflammatory mediators during pediatric cardiac operations
Journal
Annals of Thoracic Surgery
Journal Volume
61
Journal Issue
2
Pages
651-656
Date Issued
1996
Author(s)
Abstract
Background. Conventional and modified ultrafiltration was used in pediatric cardiac operations to reduce volume overload and total body water. The purpose of this study was to compare the efficacy of these techniques in removing inflammatory mediators during cardiopulmonary bypass. Methods. Fifty pediatric patients undergoing cardiac operations were randomized into a modified or conventional ultrafiltration group. Blood samples were obtained before and after ultrafiltration to assess the plasma concentrations of leukocyte elastase, tumor necrosis factor-α, interleukin-6, and interleukin-8. Results. Except for plasma concentrations of tumor necrosis factor-α in the modified ultrafiltration group, the plasma concentrations of all the mediators measured increased after ultrafiltration in both groups of patients. The volume of ultrafiltrate and the total amounts of tumor necrosis factor-α and interleukin-6 removed by ultrafiltration were significantly greater in the modified group. The concentrations of mediators in the ultrafiltrate and the ratio of ultrafiltrate to plasma concentrations of the mediators did not differ between the groups. Ultrafiltration was more efficient in removing tumor necrosis factor-α than the other mediators. Conclusions. The efficacy in removing the inflammatory mediators generated during cardiopulmonary bypass did not differ between modified and conventional ultrafiltration.
SDGs
Other Subjects
interleukin 6; interleukin 8; leukocyte elastase; tumor necrosis factor alpha; article; cardiopulmonary bypass; child; clinical trial; controlled clinical trial; controlled study; female; heart disease; human; major clinical study; male; open heart surgery; priority journal; ultrafiltration
Publisher
Elsevier USA
Type
journal article