Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia
Journal
Journal of Natural Products
Journal Volume
60
Journal Issue
6
Pages
606-608
Date Issued
1997
Author(s)
CHE-MING TENG
Abstract
Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 μM and 2 ng/mL, respectively.
SDGs
Other Subjects
aglafolin; antithrombocytic agent; arachidonic acid; rocaglamide; scopoletin; thrombocyte activating factor; unclassified drug; animal cell; antineoplastic activity; article; drug cytotoxicity; drug isolation; human; human cell; leukemia cell; mouse; nonhuman; nuclear magnetic resonance; species difference; thrombocyte aggregation; Animals; Antineoplastic Agents, Phytogenic; Benzofurans; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured; Aglaia; Aglaia elliptifolia; Animalia
Type
journal article