The future of Extracellular Vesicles as Theranostics–an ISEV meeting report
Journal
Journal of Extracellular Vesicles
Journal Volume
9
Journal Issue
1
Date Issued
2020
Author(s)
Soekmadji C
Abstract
The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on “EVs in Clinical Theranostic”. Here, we report the conclusions of roundtable discussions on the current advancement in the analysis technologies and we provide some guidelines to researchers in the field to consider the use of EVs in clinical application. The main challenges and the requirements for EV separation and characterization strategies, quality control and clinical investigation were discussed to promote the application of EVs in future clinical studies. ? 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.
Subjects
albumin; antisense oligonucleotide; CA 19-9 antigen; CD63 antigen; CD81 antigen; CD9 antigen; glypican 1; guide RNA; interleukin 6; interleukin 7; messenger RNA; tumor necrosis factor; Alzheimer disease; androgen deprivation therapy; antibody affinity; body mass; calibration; cell culture; cell growth; chromatography; Conference Paper; cytotoxicity; dietary intake; enzyme activity; erythrocyte; exercise; exosome; extracellular matrix; filtration; freeze thawing; hemolysis; human; hydrostatic filtration dialysis; in vitro study; inflammatory bowel disease; macrophage; mesenchymal stem cell; mesenchymal stroma cell; metabolomics; nonhuman; oxidative stress; precipitation; prion disease; proteomics; quality control; reproducibility; signal transduction; standardization; ultrafiltration
Other Subjects
albumin; antisense oligonucleotide; CA 19-9 antigen; CD63 antigen; CD81 antigen; CD9 antigen; glypican 1; guide RNA; interleukin 6; interleukin 7; messenger RNA; tumor necrosis factor; Alzheimer disease; androgen deprivation therapy; antibody affinity; body mass; calibration; cell culture; cell growth; chromatography; Conference Paper; cytotoxicity; dietary intake; enzyme activity; erythrocyte; exercise; exosome; extracellular matrix; filtration; freeze thawing; hemolysis; human; hydrostatic filtration dialysis; in vitro study; inflammatory bowel disease; macrophage; mesenchymal stem cell; mesenchymal stroma cell; metabolomics; nonhuman; oxidative stress; precipitation; prion disease; proteomics; quality control; reproducibility; signal transduction; standardization; ultrafiltration
Type
conference paper