Comparison between Sequential TDT method and Sequential likelihood method in Association Studies using Case-parent triad families
Date Issued
2007
Date
2007
Author(s)
Lin, Kun-Yi
DOI
zh-TW
Abstract
In this paper, we use case-parent triad families as the data structure to demonstrate how to proceed sequential linkage analysis. We adopt two types of linkage methods, the unified-parameter likelihood method and the transmission/disequilibrium test (TDT) method, to implement this sequential test procedure. Under different genetic scenarios, our simulation studies show that the unified-parameter sequential likelihood method requires less sample sizes to reach the sequential decision boundary than the TDT sequential method.
Subjects
樣本數
逐次機率比例檢定
傳遞不平衡檢定
統合參數概似函數
sample size
sequential probability ratio test
transmission/disequilibrium test
unified-parameter likelihood
Type
thesis
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