Nitric oxide is associated with poor embryo quality and pregnancy outcome in in vitro fertilization cycles
Journal
Fertility and Sterility
Journal Volume
82
Journal Issue
1
Pages
126-131
Date Issued
2004
Author(s)
Abstract
Objective To evaluate the association between follicular and serum nitric oxide (NO) levels and embryo development and outcome in IVF. Design Prospective, case-control study. Setting University hospital, tertiary medical center. Patient(s) Eighteen patients with tubal or peritoneal factor infertility and 18 female partners from couples with male factor infertility underwent controlled ovarian stimulation and IVF/intracytoplasmic sperm injection (ICSI). Intervention(s) Controlled ovarian stimulation and oocyte retrieval followed by IVF/ICSI and embryo culture. Main outcome measure(s) Degree of fragmentation of embryos and pregnancy rate. Result(s) Higher follicular NO levels were associated with advanced fragmentation of embryos. Follicular soluble Fas could not prevent embryo fragmentation. Higher serum NO levels were found among nonpregnant patients with tubal or peritoneal factor infertility. No elevated serum NO levels were found in the female partners from couples with male factor infertility. Conclusion(s) Up-regulation of serum NO is associated with implantation failure in patients with tubal or peritoneal factor infertility. ? 2004 by American Society for Reproductive Medicine.
SDGs
Other Subjects
Fas antigen; nitric oxide; adult; article; blood level; clinical article; controlled study; embryo culture; embryo development; evaluation; female; female infertility; fertilization in vitro; health center; hospital patient; human; intracytoplasmic sperm injection; male; male infertility; nidation; oocyte; outcomes research; ovary follicle; peritoneum; pregnancy; pregnancy rate; priority journal; prospective study; qualitative analysis; solubility; stimulation; university hospital; upregulation; uterine tube; Adult; Case-Control Studies; Embryo; Female; Fertilization in Vitro; Humans; Infertility; Infertility, Female; Infertility, Male; Male; Nitric Oxide; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Outcome; Prospective Studies; Sperm Injections, Intracytoplasmic
Type
journal article