Serum soluble interleukin-2 receptor in patients with end-stage renal disease on hemodialysis
Journal
Dialysis and Transplantation
Journal Volume
24
Journal Issue
8
Pages
459-463+477
Date Issued
1995
Author(s)
Abstract
The serum soluble interleukin-2 receptor (SIL2R) is a marker of T cell activation in many disease entities. This study evaluated the serum SIL2R level in patients with end-stage renal disease (ESRD) and explored the possible association between the SIL2R and the immunodeficient status in uremic patients. The SIL2R levels were measured before and after hemodialysis in 41 patients. Thirty-five healthy volunteers with normal renal function served as the control group. It was found that the predialysis serum SIL2R levels were significantly higher than those of the control group, and the levels correlated well with the serum globulin level. There was, however, no definite relationship between SIL2R and other clinical parameters such as the creatinine and albumin levels, age, dialysis duration, or body weight. There were also no significant differences between males and females, different dialysates (acetate vs. bicarbonate), dialyzers (cuprophane vs. polymethylmethacrylate), or between patients with different underlying diseases. When comparing the concentration change during the dialysis session, the postdialysis levels were significantly higher than the predialysis levels, but after correcting for the factor of hemoconcentration, the levels were similar. The results of the study, combined with previous findings, imply that the high serum SIL2R level in hemodialysis patients could not be explained by a single factor, and that lymphocyte preactivation and decreased renal clearance might be involved. This high serum level would contribute to the immunodeficient state in uremic patients.
SDGs
Other Subjects
acetic acid; albumin; bicarbonate; creatinine; cuprophane; globulin; interleukin 2 receptor; poly(methyl methacrylate); adolescent; adult; age; aged; article; body weight; clinical article; controlled study; dialysate; dialysis membrane; female; hemodialysis; human; immune deficiency; kidney failure; male; priority journal
Type
journal article