Long-term disease-free survival after autologous bone marrow transplantation in a primary plasma cell leukaemia: detection of minimal residual disease in the transplant marrow by third-complementarity-determining region-specific probes
Journal
British Journal of Haematology
Journal Volume
89
Journal Issue
4
Pages
914-916
Date Issued
1995
Author(s)
Abstract
Primary plasma cell leukaemia (PPCL) is a rare form of plasma cell neoplasm. Treatments of PPCL have been most disappointing. A patient with PPCL received high?dose melphalan plus total body irradiation and autologous bone marrow transplantation (ABMT). By using third?complementarity?determining region (CDRIII)?specific probes, minimal residual disease (MRD) was detected in remission marrow, collected 1 month before ABMT. MRD was no longer detected by CDRIII?specific probes 6, 19 and 26 months after transplantation. The patient remained in complete remission up to 59 months after ABMT. Copyright ? 1995, Wiley Blackwell. All rights reserved
SDGs
Other Subjects
cyclophosphamide; doxorubicin; melphalan; prednisone; vincristine; adult; article; autologous bone marrow transplantation; case report; female; human; minimal residual disease; normal human; plasma cell leukemia; priority journal; survival; whole body radiation; Adult; Base Sequence; Bone Marrow Transplantation; Case Report; Disease-Free Survival; DNA Probes; Female; Human; Leukemia, Plasmacytic; Molecular Sequence Data; Neoplasm, Residual; Support, Non-U.S. Gov't; Transplantation, Homologous
Type
journal article