High-contrast paramagnetic fluorescent mesoporous silica nanorods as a multifunctional cell-imaging probe
Journal
Small
Journal Volume
4
Journal Issue
2
Pages
186-191
Date Issued
2008
Author(s)
Abstract
The development of a new multifunctional mesoporous silica nanorod that features green fluorescence and paramagnetism, is analyzed. The multifunctional nanorods were synthesized by surfactant-templated self-assembly, which can be used as a contrast agent in magnetic resonance imaging (MRI). These nanorods were washed with water and ethanol and heated at 60°C for 24 h to remove the surfactant. The surfactant-free nanorods, Dye@MSN-R, were mixed with GdCl 3-6H2O in 75% aqueous methanol and stirred at 40°C for 18 h to form the multifuctional nanorods Gd-Dye@MSN-R. The morphology and size distribution of Gd-Dye@MSN-R were examined by transmission electron microscopy (TEM). The bifunctional properties of nanorods were also analyzed to use as a cell marker. Results show that nanorods exhibit potential in monitoring cell trafficking and cancer cell metastasis, and drug/DNA delivery effectively.
SDGs
Other Subjects
Imaging systems; Magnetic properties; Magnetic resonance imaging; Mesoporous materials; Paramagnetism; Silica; Cell imaging probes; Fluorescent probes; Nanorods; biological marker; coloring agent; contrast medium; fluorescent dye; nanotube; silicon dioxide; animal; article; cell strain 3T3; chemistry; drug delivery system; methodology; molecular probe; mouse; nanotechnology; nuclear magnetic resonance imaging; powder diffraction; transmission electron microscopy; ultrastructure; 3T3-L1 Cells; Animals; Biological Markers; Coloring Agents; Contrast Media; Drug Delivery Systems; Fluorescent Dyes; Magnetic Resonance Imaging; Mice; Microscopy, Electron, Transmission; Molecular Probes; Nanotechnology; Nanotubes; Powder Diffraction; Silicon Dioxide
Type
journal article