Diosgenin, a plant-derived sapogenin, enhances regulatory T-Cell immunity in the intestine of mice with food allergy
Resource
J Nat Prod,73(6),1033-1037
Journal
Journal of Natural Products
Journal Volume
73
Journal Issue
6
Pages
1033-1037
Date Issued
2010
Author(s)
Abstract
It was hypothesized that the suppressive effect of diosgenin (1) on the intestinal T helper (Th)2 responses is associated with an enhancement of the regulatory T-cell immunity. Ovalbumin (OVA)-sensitized BALB/c mice were gavaged daily with 1 and received repeatedly oral OVA challenges to induce intestinal allergic responses. The expression of Th2- and Treg-related cytokines and transcription factors was examined by immunohistochemical staining and RT-PCR. Administration of 1 markedly attenuated the intestinal expression of interleukin (IL)-4 and GATA3. In addition, administration of 1 reversed the diminished density of intestinal Foxp3(+) cells induced by OVA oral challenges and enhanced the expression of IL-10 by Foxp3(+) cells markedly. These results suggest that the suppressive effect of 1 on allergen-induced intestinal Th2 responses is closely associated with an up-regulation of the regulatory T-cell immunity in the inflammatory site.
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
JNP 2010.pdf
Size
4.32 MB
Format
Adobe PDF
Checksum
(MD5):af770749cce35019cc7ea79c66efe2d2