Effect of Spontaneous Physiology on Characterizing the Resting-State Functional Magnetic Resonance Imaging of Alzheimer’s Disease Patients
Date Issued
2016
Date
2016
Author(s)
Li, Yi-Tien
Abstract
Studies have reported that the Alzheimer''s disease (AD) patients have different default mode network (DMN) characteristics from normal subjects. However, few studies considered the contamination of physiological noise in DMN characterization. Here, we study the impact of spontaneous physiology on characterizing the DMN of AD patients. Cardiac and respiratory cycles were respectively recorded using a pulse oximeter and a respiration belt concurrently with resting-state fMRI measurements. We used RETROICOR to remove phase-locked physiological artifacts. Other low frequency physiological effects of the same phase but different amplitudes (for respiration variations) or intervals (for heart rate) were corrected by RVHRCOR. Without correcting physiological noise, AD patients show significantly different DMN characteristics from the healthy subjects. However, this difference became less significant physiological noise correction. We also found that the physiological response functions were different between AD patients and healthy subjects. Our results suggest the importance of controlling spontaneous physiology in using hemodynamic responses to achieve more sensitive and specific characterization of the DMN in AD patients and healthy subjects.
Subjects
Alzheimer’s disease
resting-state
default mode network
physiological noise
fMRI
aging
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
ntu-105-R03548034-1.pdf
Size
23.54 KB
Format
Adobe PDF
Checksum
(MD5):fad5a04b3a62be590b8feaffc3da3561