A randomized crossover evaluation of antianginal efficacy and safety of nitrolingual-spray and nitroglycerin tablet form in coronary artery disease patients
Journal
Cardiology
Journal Volume
93
Journal Issue
3
Pages
137-141
Date Issued
2000
Author(s)
Abstract
Twenty-eight coronary artery disease patients with more than 50% stenosis in at least one major coronary artery completed this randomized crossover clinical trial for the comparison of efficacy and safety of Nitrolingual-Spray and nitroglycerin (NTG) tablets. Exercise time was lengthened to 399.1 s (spray) or 408.5 s (tablets), compared to a baseline of 387.3 s. Ischemic burden decreased to about -4.0 mm with both forms, compared to -7.5 mm at baseline (ANOVA: p = 0.003). The ischemic time improved to 137.2 s (spray) or 152.9 s (tablets), compared to 253.4 s at baseline (ANOVA: p = 0.005). Patients taking tablets experienced more episodes of hypotension and/or headache compared to patients taking the spray. Nitrolingual-Spray is as effective and safe as NTG tablets for the treatment of symptomatic coronary heart disease. Copyright (C) 2000 S. Karger AG, Basel.
Subjects
Clinical trial; Coronary artery disease; Nitroglycerin; Treadmill exercise test
SDGs
Other Subjects
glyceryl trinitrate; nitrolingual spray; adult; aerosol; aged; article; clinical article; clinical trial; controlled clinical trial; controlled study; coronary artery disease; crossover procedure; drug efficacy; drug safety; exercise test; female; headache; human; hypotension; male; priority journal; randomized controlled trial; tablet; treadmill exercise; vertigo
Publisher
S. Karger AG
Type
journal article