Cyano Derivatives of 7-Aminoquinoline that are Highly Emissive in Water: Potential for Sensing Applications
Journal
CHEMISTRY-A EUROPEAN JOURNAL
Journal Volume
27
Journal Issue
30
Pages
8040-8047
Date Issued
2021
Author(s)
Chang, KH
Chao, WC
Yang, YH
Wu, CH
Li, ZB
Chen, HC
Chou, YT
Ho, JAA
Li, XC
Peng, YC
Liao, YC
Liu, KM
Chao, CM
Abstract
Q) show virtually no emission, which makes them suitable to be used as recognition agents in azide reactions based on fluorescence recovery. Moreover, conjugation of 6CN-7AQ with a hydrophobic biomembrane-penetration peptide PFVYLI renders a nearly non-emissive 6CN-7AQ-PFVYLI composite, which can be digested by proteinase K, recovering the highly emissive 6CN-7AQ with ∼200-fold enhancement. The result provides an effective early confirmation for RT-qPCR in viral detection.
Type
journal article