Epidemiology and antifungal susceptibilities of yeast isolates causing invasive infections across urban Beijing, China
Journal
Future Microbiology
Journal Volume
12
Journal Issue
12
Pages
1075-1086
Date Issued
2017
Author(s)
Guo L.-N.
Xiao M.
Cao B.
Qu F.
Zhan Y.-L.
Hu Y.-J.
Wang X.-R.
Liang G.-W.
Gu H.-T.
Qi J.
Yuan H.
Min R.
Wang F.-Y.
Liu L.-J.
Wang H.-B.
Jiang W.
Duan X.-G.
Xu W.-J.
Yu Y.-H.
Su J.-R.
Zhang J.-Z.
Nong J.-Q.
Liu S.-M.
Li J.
Liu J.-T.
Yue Z.-G.
Yang D.
Guo J.
Zhao R.
Zhang Y.-N.
Yang X.-M.
Liu X.-Q.
Xu Y.-C.
Abstract
AIM: To investigate the species distribution and antifungal susceptibility profiles of yeast isolates causing invasive infections across Beijing. MATERIALS & METHODS: A total of 1201 yeast isolates recovered from blood and other sterile body fluids were correctly identified by matrix-assisted laser desorption/ionization TOF MS supplemented by DNA sequencing. Antifungal susceptibility testing was performed according to the Clinical and Laboratory Standards Institute broth microdilution method. RESULTS: Candida (95.5%) remained the most common yeast species isolated; Candida albicans (38.8%) and Candida parapsilosis (22.6%) were the leading species of candidemia. Azole resistances were mainly observed in Candida glabrata and Candida tropicalis isolates. CONCLUSION: This study outlined the epidemiologic data of invasive yeast infections and highlighted the need for continuous monitoring of azole resistances among C. glabrata and C. tropicalis isolates in Beijing.
Type
journal article