A novel prenylated C6-C3 compound with estrogen-like activity from the fruits of Illicium arborescens
Journal
Phytochemistry Letters
Journal Volume
6
Journal Issue
3
Pages
397-402
Date Issued
2013
Author(s)
Liaw C.-C.
Chen Y.-C.
Fazary A.E.
Hsieh J.-L.
Chen S.-Y.
Chien C.-T.
Sheu S.-Y.
Kuo Y.-H.
Shen Y.-C.
Abstract
A novel C6-C3 prenylated compound, illicarborene A (1), together with illioliganfunone D (2), 1-allyl-3,5-dimethoxy-4-(3-methylbut-2-enyloxy)benzene (3), ()-illicinone A (4), ()-illicinone B (5) and ()-illicinone A derivative (6) was isolated and characterized from the fruits of Illicium arborescens Hayata. Compound 1 possesses a new class of tricyclic 6/6/5 ring system. The structure of 1 was determined by spectroscopic analysis such as 1H-1H COSY, HMQC, HMBC, and NOESY, and confirmed by chemical reaction to yield 7. Compounds 1-5 were found to increase proliferative activity in primary cell culture of osteoblast cells. © 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Publisher
Elsevier Ltd
Type
journal article