CTNNB1 mutation in aldosterone producing Adenoma
Journal
Endocrinology and Metabolism
Journal Volume
32
Journal Issue
3
Pages
332-338
Date Issued
2017
Author(s)
Abstract
Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1) mutation in APAs has been recently described and discussed in the literature. However, significant knowledge gaps still remain regarding the prevalence, clinical characteristics, pathophysiology, and outcomes in APA patients harboring CTNNB1 mutations. Aberrant activation of the Wnt/β-catenin signaling pathway will further modulate tumorigenesis. We also discuss the recent knowledge of CTNNB1 mutation in adrenal adenomas. ? 2017 Korean Endocrine Society.
SDGs
Other Subjects
aldosterone synthase; beta catenin; catenin beta 1; cytochrome p450 11b1; cytochrome P450 family 11; gonadorelin receptor; hydrocortisone; luteinizing hormone; luteinizing hormone receptor; unclassified drug; adrenal cortex adenoma; adrenalectomy; cancer patient; clinical outcome; Cushing syndrome; gene mutation; human; nonhuman; primary hyperaldosteronism; Review
Publisher
Korean Endocrine Society
Type
review