URINARY N-ACETYL-BETA-GLUCOSAMINIDASE IN CHILDREN WITH IDIOPATHIC NEPHROTIC SYNDROME
Resource
中華民國小兒科醫學會雜誌 v.32 n.5 pp.286-290
Journal
中華民國小兒科醫學會雜誌,v.32
Journal Issue
n.5
Pages
286-290
Date Issued
1991
Date
1991
Author(s)
TSAU, YONG-KWEI
CHEN, CHIUNG-HUI
YANG, LI-FANG
SHEU, JI-NAN
Abstract
本研究包含21位腎病症候羣孩童，年齡2至15歲，共計35次同時測得之24小時尿蛋白及尿中NAG做線性迴歸分析。在急性期時，18位病童之尿中NAG（平均77.3±112.1，範圍10.3至450.7u/gCr)高於正常平均值兩個標准差以上，3位則有正常之尿中NAG。經線性迴歸分析，NAG和尿蛋白並無關連(r=0.24, p>0.05)，雖然在對數轉換後稍有關連，但相關性不佳(r=0.36, p=0.037)。比較8位病童急性期及緩解後之尿中NAG，發現並無統計學上有意義的變化。本研究認爲腎病症候羣孩童之尿中NAG增加並非由於腎絲球滲透性之改變，可能只是反應合併腎小管功能失常或腎小管間質受到侵犯的疾病活性。
Twenty-one nephrotic children, aged 2 to 15 years, were studied for their urinary N-acetyl-beta-glucosaminidase (NAG) and daily urinary total protein, in a total of 35 episodes. Among them, 18 patients had urinary NAG levels (773±112.1 u/g Cr) above normal mean +2 SD for age, while 3 had normal levels during the nephrotic stage. No or poor correlation was found between urinary protein and NAG. In eight of these patients, urinary NAG levels during heavy proteinuria and after remission were evaluated. No significant change was detected. These observations suggest that urinary NAG excretion in nephrotic children is not caused by an increased glomerular permeability to macromolecules. Instead, the elevated urinary NAG may reflect the activity of associated renal tubular dysfunction or tubulointerstitial involvement in the nephrotic syndrome.
Type
journal article