MK-801 SUPPRESSES MURICIDAL BEHAVIOR BUT NOT LOCOMOTION IN OLFACTORY BULBECTOMIZED RATS: INVOLVEMENT OF NMDA RECEPTORS
Resource
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR v.77 n.3 pp.641~646
Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Journal Volume
v.77
Journal Issue
n.3
Pages
641-646
Date Issued
2004
Date
2004
Author(s)
HO, YING-JUI
CHEN, KUANG-HO
TAI, MEI-YUN
TSAI, YUAN-FEEN
Abstract
In rats, olfactory bulbectomy (OBX) causes changes in glutamatergic function in the amygdala (AMG) and induces mouse-killing behavior (MKB). The medial ANIG (mAMG) plays an important role in the initiation and maintenance of OBX- induced MKB. In the present study, systemic injection or intra-mAMG perfusion of (+)-5-methyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) was used to determine the effects of MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, on the expression of OBX-induced MKB in male Wistar rats that had undergone OBX 1 month previously. The effects of MK-801 on locomotion in OBX rats were also examined using the open-field test. Intraperitoneal injection of MK-801 at doses of 0.10 and 0.15 mg/kg resulted in reversible suppression of MKB, the effect being maximal within 1 hr after drug treatment, then gradually disappearing over 6 It. Locomotor distance in OBX rats was not affected using 0.10 mg/kg of MK-801, but increased after treatment with 0.15 mg/kg of MK-801; both doses, however, caused the rats to spend longer in the central area of the open field. MKB was also reversibly suppressed by local perfusion of 1 mM MK-801 at a rate of 1 mul/min into the mAMG through microdialysis probes. These results suggest that NMDA receptors, at least, in the mAMG, are involved in the expression of OBX-induced MKB. (C) 2004 Elsevier Inc. All rights reserved
Subjects
olfactory bulbectomy
NMDA receptor
MK-801
mouse-killing behavior
amygdala
glutamate
Type
journal article