Assessing Effects of Disease Genes, Gene-Environment and Gene-Gene Interactions Using the Case-Spouse Design
Date Issued
2004
Date
2004
Author(s)
Chang, Chin-Hao
DOI
zh-TW
Abstract
It is important to characterize the effects of gene, gene-environment, and gene-gene interactions in the study of human complex diseases. The potential bias is raised due to population stratification/admixture in the traditional case-control study. Family-based study, like case-parents and case-siblings study, can circumvent the problem of bias. However, it is difficult to recruit parents or siblings of cases in studies of adult-onset disease. Case-only study can be implemented easily, but it still faces the stratification bias for assessing gene-environment and gene-gene interactions. The novel study, case-spouse study, reduces the bias if the population is stratification or admixture slightly. The estimates have the corresponding coverage probability. It is more convenient to collect the spouse then the parents or siblings of cases. The case-spouse design is an alternative for assessing the genotype relative risks, gene-environment, and gene-gene interaction coefficients.
Subjects
流行病學方法學
相關研究法
基因特徵
遺傳流行病學
epidemiologic methods
association study
genetic epidemiology
gene characterization
SDGs
Type
thesis
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