Role of tumor necrosis factor‐α in the regulation of activated synovial T cell growth: Downregulation of synovial T cells in rheumatoid arthritis patients
Journal
European Journal of Immunology
Journal Volume
25
Journal Issue
12
Pages
3243-3248
Date Issued
1995
Author(s)
Abstract
To characterize the role of tumor necrosis factor (TNF)?α in regulating synovial T cell growth, cell cycle progression associated with TNF?α in mitogen?activated synovial T cells of patients with rheumatoid arthritis (RA) were analyzed. After mitogen stimulation, the majority of synovial T cells in RA patients accumulated in S?phase. Anti?human TNF?α monoclonal antibody and soluble recombinant human TNF receptor (rhTNFR) can block S?phase accumulation. Furthermore, synovial fluid (SF) from RA patients was able to inhibit the proliferation of these S?phase?accumulated T cells. These data indicate that TNF?α could regulate activated synovial T cell growth by driving them into S?phase. Combined with the activities of other components of SF, TNF?α seems to play an important role in down?regulating activated synovial T cells in RA patients. In addition, the elevated level of soluble TNFR in the SF of disease?active RA patients is believed to be associated with the promotion of synovial T cell responses. Copyright ? 1995 WILEY?VCH Verlag GmbH & Co. KGaA, Weinheim
Subjects
Cell cycle; Rheumatoid arthritis; T cell; Tumor necrosis factor?α
SDGs
Other Subjects
monoclonal antibody; tumor necrosis factor alpha; tumor necrosis factor receptor; adherent cell; article; cell cycle; cell growth; human; human cell; priority journal; rheumatoid arthritis; synovial fluid; synoviocyte; t lymphocyte; t lymphocyte activation; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Down-Regulation; Humans; Lymphocyte Activation; Phytohemagglutinins; S Phase; Synovial Fluid; T-Lymphocytes; Tumor Necrosis Factor-alpha
Type
journal article