Study on Optical Imaging Techniques for Biomedical Applications
Date Issued
2009
Date
2009
Author(s)
Wang, Yih-Ming
Abstract
Development of biomedical imaging systems is an important issue for diagnosis applications. However, optical properties of biological tissues have not been well understood yet. We have measured transmitted signals with time-, aperture-, and angle-gating for comparison in micro-sphere suspension, chicken breast and chicken liver tissues. Although all the three gating methods might lead to effective biological imaging, they basically collected different portions of transmitted signals for imaging. For biological tissues of different structures, different gating methods might lead to different levels of imaging quality. It is worth exploring a most suitable gating method for a particular kind of tissue. ptical coherence tomography (OCT) has been applied to the scans of various portions of biological tissue, and used for the diagnosis of various diseases. In many situations, such as the pathological process in tissue, changes in the sample scattering property are so small that measurement is difficult. Therefore, for clinical applications, imaging contrast enhancement is an important issue. Polarization-sensitive optical coherence tomography (PSOCT) combines the depth resolution of OCT with polarization-dependent scanning to image the optical birefringence of biological tissues. In the past few decades, hypercholesterolemia has emerged to be a major health threat in the developed world. It has been reported that accumulation of excess cholesterol in the liver results in inflammation and fibrosis. We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with PSOCT. Tissue birefringence is evaluated through the measurement of phase retardation.
Subjects
gating method
optical coherence tomography
hypercholesterolemic liver
Type
thesis
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