Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population
Journal
DNA repair
Journal Volume
78
Pages
1-6
Date Issued
2019-06
Author(s)
Abstract
Evidence indicates that the age-related neuropathological mechanisms associated with DNA repair genes may contribute to cognitive aging and Alzheimer's disease. In this study, we hypothesize that single nucleotide polymorphisms (SNPs) within 155 DNA repair genes may be linked to cognitive aging independently and/or through complex interactions in an older Taiwanese population. A total of 3,730 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed. Mini-Mental State Examination (MMSE) was administered to all subjects, and MMSE scores were used to measure cognitive functions. Our data showed that out of 1,652 SNPs, the rs1776181 (P = 1.47 × 10-5), rs1776177 (P = 8.42 × 10-7), rs1635510 (P = 7.97 × 10-6), and rs2526698 (P = 7.06 × 10-6) SNPs in the EXO1 gene were associated with cognitive aging. The association with these SNP remained significant after performing Bonferroni correction. Additionally, we found that interactions between the EXO1 and RAD51C genes influenced cognitive aging (P = 0.002). Finally, we pinpointed the influence of interactions between EXO1 and physical activity (P < 0.001) as well as between DCLRE1C and physical activity (P < 0.001). Our study indicated that DNA repair genes may contribute to susceptibility in cognitive aging independently as well as through gene-gene and gene-physical interactions.
Subjects
Alzheimer’s diseases; Cognitive aging; Cognitive impairment; Gene-gene interactions; Neurodegeneration; Single nucleotide polymorphisms
Alzheimer's diseases; Cognitive aging; Cognitive impairment; Gene-gene interactions; Neurodegeneration; Single nucleotide polymorphisms
SDGs
Other Subjects
DNA cross link repair 1c protein; exonuclease; exonuclease 1; nucleic acid binding protein; Rad51 protein; Rad51C protein; unclassified drug; DNA ligase; EXO1 protein, human; exodeoxyribonuclease; adult; aged; aging; Article; biobank; cognition; cognitive aging; cognitive defect; cohort analysis; controlled study; DNA repair; female; gene expression; human; major clinical study; male; middle aged; Mini Mental State Examination; multicenter study; physical activity; priority journal; protein protein interaction; single nucleotide polymorphism; Taiwanese; DNA repair; genetics; genotype; Taiwan; Aged; Cognitive Aging; DNA Repair; DNA Repair Enzymes; Exodeoxyribonucleases; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Taiwan
Publisher
ELSEVIER SCIENCE BV
Type
journal article