Study of Gastric Helicobacter-Like Organisms (GHLOs) in Dogs and Cats
Date Issued
2009
Date
2009
Author(s)
Chen, Ping-Hsu
Abstract
Helicobacteriosis is one of the most prevalent infectious diseases in humans and animals. Multiple gastric helicobacter-like organisms (GHLOs) have been found in human and many animal species and some of them have been reported to cause diseases in humans, dogs, and cats. In Taiwan, the prevalence of helicobacter infection in dogs and cats is still unclear and the zoonotic research of helicobacteriosis is also very limited. The purpose of this study is using PCR assay to identify the helicobacter infected dogs and cats in Taiwan, to determine the prevalence of helicobacteriosis in pet dogs and cats, and to evaluate the zoonotic risk of helicobacter infection between pets and humans. In this study, tissues collected via gastric biopsy or at necropsy from 36 pets were screened by the Helicobacter generic PCR assay and positive samples were further analyed for the sequence of 16S rRNA gene. A total of 18 samples were found to be helicobacter positive on helicoabcters based on the Helicobacter generic PCR result (prevalence of 50%). The 16S rRNA gene sequences of 17 samples were determined and compared to the of previously reported gastric helicobacters. The analysis results revealed the 13 samples were closely related to previously identified zoonotic helicobactes, 6 samples similar to “H. heilmannii”, 5 samples similar to “H. heilmannii” and H. bizzozeronii and 2 samples similar to H. felis and H. salomonis. Four different samples were distinctly different from currently known gastric helicobacters in dogs and cats and were suggested to be newly identified GHLOs. In conclusion, gastric helicobacteriosis is highly prevalent in pet dogs and cats in Taiwan. Potential risks of zoonotic helicobacteriosis of dogs, cats, and humans are at present uncertain, but with existing possibility. Several newly identified GHLOs are recognized and further study is required for the pathogenesis and zoonotic risk of these GHLOs.
Subjects
canine helicobacteriosis
feline helicobacteriosis
Helicobacter generic PCR assay
GHLOs prevalence
zoonotic helicobacteriosis
SDGs
Type
thesis
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