Structural isomers and binding sites of guanine-rich quadruplexes investigated by induced circular dichroism of thionin: Loops and tails
Journal
Journal of Biomolecular Structure and Dynamics
Journal Volume
21
Journal Issue
1
Pages
135-140
Date Issued
2003
Author(s)
Abstract
Induced circular dichroism has been used to study the binding of thionin molecule to twelve guanine-rich quadruplexes. Substituting the base in the loops and varying the length of the tails could substantial change the induced circular dichroism spectra, which allow us to distinguish structural isomers and to determine the binding sites of quadruplexes. Our results show that external stacking on the end surface of the G-quartet associated with electrostatic interaction with the loops or tails is the major binding mode of thionin with these G-quadruplexes.
Type
journal article