Measurement of pulse wave velocity in spinal cord injury and stroke patients
Date Issued
2005-07-31
Date
2005-07-31
Author(s)
王亭貴
DOI
932314B002100
Abstract
Pulse wave velocity (PWV) has
been used to evaluate the atherosclerosis,
and further to measure the status of
autonomic nerve recently, especially the
sympathetic activity. Thermal change
frequent occurred in hemiplegic side of
strokes patients and sometimes
sympathetic dystrophy developed later
on. The method has beenused to
measure the sympathetic activity is
either unstable or invasive till now. The
present project attempted to measure the
pulse wave simultaneously at four limbs
by pressure receptors, and use the
electrocardiogram as the reference to
synchronize the recorded pulse wave at
different vessels. With the pulse wave
velocity of different vessels, we can
understand the local sympathetic nerve
activity in different diseases and
different sites. We tested the reliability
of self-designed machine and measured
the PWV change of hemiplegic stroke
patients.
Fifteen normal subjects were
included in the project for testing the
reliability of machine. The subjects were
measured by two independent observers
and at two different points. Another 15
stroke patients were included in this
project. There were 10 male and 5
female with the mean age of 59 years
old and after stroke around 52 days. The
pulse wave was detected at the radial
artery, brachial artery, popliteal artery,
and tibial artery simultaneously. The
result showed that the coefficient of
variance (CV) of inter-reliability was
less than 5%, but the CV of
intra-reliability of the machine was
10-12%. When the cuff pressure
increased from 20 to 60 mmHg, the CV
of the machine significantly decreased,
but the velocity of pulse wave also
reduced 6 to 8 %. In stroke patients, the
PWV of upper limb of hemiplegic side
was slowed than that of the sound side
( 10.7 + 2.7 m/sec vs 9.7+ 2.3 m/sec) but
not statically significant ( P=0.17). For
lower limbs, the PWV of hemiplegic
side was also slower than that of sound
side (9.8 + 2.7 m/sec vs 9.0+ 3.2 m/sec)
without statically significant (p=0.10).
However, the PWV of upper limbs was
faster than that of lower limbs
significantly.
We conclude that the self-designed
PWV machine has adequate reliability. It
can be used to evaluate the sympathetic
activity. The PWV of hemiplegic side in
stroke patients seemed faster then that of
sound side. Included more cases is
indicted to draw a more definite
conclusion.
Subjects
pulse wave velocity
sympathetic nerve activity
cerebrovascular accident
atherosclerosis
Publisher
臺北市：國立臺灣大學醫學院復健科
Type
other
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