The Combination of Daptomycin with Fosfomycin is More Effective than Daptomycin Alone in Reducing Mortality of Vancomycin-Resistant Enterococcal Bloodstream Infections: A Retrospective, Comparative Cohort Study
Journal
Infectious diseases and therapy
Journal Volume
12
Journal Issue
2
Pages
589 - 606
Date Issued
2023-01-11
Author(s)
Yang, Jia-Ling
Lin, Chi-Ying
Huang, Sung-Hsi
Abstract
High-dose daptomycin-based combinations are recommended for vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI). Preclinical data have shown a synergistic effect of daptomycin/fosfomycin combinations against VRE. However, clinical studies comparing daptomycin monotherapy with daptomycin/fosfomycin combinations are unavailable.
Subjects
Combination; Daptomycin; Fosfomycin; Mortality; Vancomycin-resistant enterococci
SDGs
Publisher
SPRINGER LONDON LTD
Type
journal article