Non-Hodgkin's Lymphoma in Patients With Human Immunodeficiency Virus Infection in Taiwan
Journal
Journal of Microbiology, Immunology and Infection
Journal Volume
43
Journal Issue
4
Pages
278-284
Date Issued
2010
Author(s)
Abstract
Background/Purpose: Non-Hodgkin's lymphoma (NHL) is the second most common acquired immunodeficiency syndrome-defining malignancy with a high mortality rate. This study aimed to describe changes in the incidence and clinical characteristics of NHL in human immunodeficiency virus (HIV)-infected patients in a referral hospital for HIV care. Methods: The medical records of HIV-infected patients diagnosed with NHL between June 1994 and December 2006 were retrospectively reviewed. Risk stratification of each patient was evaluated using the International Prognostic Index (IPI). Case patients were followed at least for 2 years to assess the 2-year survival rates. Results: During the 12-year period, 38 HIV-infected patients were diagnosed with NHL. Their median cluster of differentiation 4 count was 82 cells/μL (range, 2-477 cells/μL) at diagnosis. Before the introduction of highly active antiretroviral therapy (HAART) in April 1997, 9/175 HIV-infected patients (5.1%) developed NHL compared with 29/1,386 patients (2.1%) in the HAART era (p < 0.05). Although the 2-year survival rate did not differ significantly between patients diagnosed in the pre-HAART era (22.2%) and those diagnosed in the HAART era (24.1%), patients receiving HAART for more than 6 months had better survival rates (p < 0.05). A low IPI score was a good prognostic factor predictive of a patient's outcome. Conclusion: The incidence of NHL in HIV-infected patients declined significantly in the HAART era. Despite the introduction of HAART, the short-term survival of the patients with NHL remained poor. The IPI was a good predictor for survival. ? 2010 Taiwan Society of Microbiology.
SDGs
Other Subjects
antiretrovirus agent; anti human immunodeficiency virus agent; adult; article; CD4 lymphocyte count; clinical article; female; follow up; highly active antiretroviral therapy; histopathology; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; incidence; male; medical record review; nonhodgkin lymphoma; nonhuman; prognosis; retrospective study; risk assessment; survival rate; Taiwan; trend study; aged; complication; HIV Infections; Lymphoma, Non-Hodgkin; middle aged; mortality; pathology; survival; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Incidence; Lymphoma, Non-Hodgkin; Male; Middle Aged; Prognosis; Retrospective Studies; Survival Analysis; Taiwan; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Incidence; Lymphoma, Non-Hodgkin; Male; Middle Aged; Prognosis; Retrospective Studies; Survival Analysis; Taiwan
Type
journal article