Detection of hepatitis b surface gene mutation in carrier children with or without immunoprophylaxis at birth
Journal
Journal of Infectious Diseases
Journal Volume
176
Journal Issue
2
Pages
427-430
Date Issued
1997
Abstract
To investigate the clinical significance of mutation in hepatitis B virus (HBV) surface gene, DNA sequence analysis of the 'a' determinant was performed on sera from 27 carrier children with immunoprophylaxis, their mothers, and 21 carriers without vaccination. A precore mutant (G to A) at nucleotide 1896 was detected in sera from 11 carriers without vaccination. Mutations in the 'a' determinant were detected in 6 (22%) of the vaccinated children. Four HBV strains showed a Gly-to-Arg mutation at the 145th codon of the surface gene. Amino acid substitutions at amino acid 133 and 144 were noted in the other 2 children. Only 1 mother had the same predominant strain of mutant virus as her child. These observations indicate that immune pressure exerted by immunoprophylaxis at birth may select for a mutant virus.
SDGs
Other Subjects
hepatitis B surface antibody; amino acid substitution; antigenicity; article; birth; child; DNA sequence; gene mutation; hepatitis B; human; immune response; immunoprophylaxis; priority journal; sequence homology; vaccination; virus carrier; virus detection; virus neutralization
Publisher
Oxford University Press
Type
journal article